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Symbol
Name
ID

Lep
leptin
MGI:104663

Phenotype annotations related to hematopoietic system

Darker colors indicate more annotations

Human Phenotypes	Decreased T cell activation	Decreased proportion of CD4-positive helper T cells
Disease(s) Associated with LEP	Decreased T cell activation	Decreased proportion of CD4-positive helper T cells
congenital leptin deficiency

Mouse Phenotypes		abnormal osteoclast differentiation	decreased T cell proliferation	decreased NK cell number	decreased CD4-positive, alpha-beta T cell number	increased macrophage cell number	decreased spleen weight	decreased splenocyte number	abnormal microglial cell physiology
Availability	Mouse Genotype	abnormal osteoclast differentiation	decreased T cell proliferation	decreased NK cell number	decreased CD4-positive, alpha-beta T cell number	increased macrophage cell number	decreased spleen weight	decreased splenocyte number	abnormal microglial cell physiology
	Lep^m1Yst/Lep^m1Yst
	Lep^ob/Lep^ob
	Lep^{tm1b(EUCOMM)Hmgu}/Lep^{tm1b(EUCOMM)Hmgu}

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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